Excelente post do Yahoo! User Interface Blog sobre os desafios no desenho de interface para dispositivos mobile:

The single most important concept to master when designing mobile device interfaces is “context”. The context in which an application is used and the context of how information is input are both key issues; each must be understood before a well crafted design may be implemented. When these two notions of context are explored, it becomes clear that designing for a mobile device can lead to a solution that is worlds different than its desktop equivalent. Continua no Y! UI Blog